Advocin-180 50 ml injectable (bovine)

ADVOCATION 180 Anti-infective in injectable solution Laboratory PFIZER, SA Expert form Injectable solution (Sol.i.) Composition per ml: Danofloxacin (as mesylate) 180,00 mg. Pharmacological properties Danofloxacin is a synthetic antimicrobial agent from the group of fluoroquinolones. Activity The antimicrobial activity of danofloxacin is based on the inhibition of microbial DNA gyrase and the topoisomerase IV. The inhibitory effect is found in the second phase of the enzymatic process, when separate the functions of breaking and melting. Produces a stable complex between the enzyme and DNA. He The result is the interruption of DNA replication and transcription. Interactions and incompatibilities None known. Indications and target species Cattle: Treatment of bovine respiratory disease caused by Mannheimia haemolytica, Pasteurella multocida and Histophilus somni sensitive to danofloxacin. mastitis treatment acute bovine disease caused by Escherichia coli, sensitive to danofloxacin. Neonatal calves: Treatment of enteric infections caused by susceptible Escherichia coli to danofloxacin. Contraindications Do not use in case of known hypersensitivity to the active ingredients, to other (fluoro)quinolones or to any ingredient of the product. efectos secundarios • In very rare cases, immediate anaphylactic shock may occur in sensitive animals or delayed after injection. • Subcutaneous injection of the product causes a moderate inflammatory response in the tissue. surrounding the injection site. The resulting injuries can last up to 30 days. Route of administration Subcutaneous or intravenous. Posology 6 mg/kg body weight (1 ml/30 kg body weight) as a single injection subcutaneously or intravenous. If clinical signs of respiratory or enteric disease persist after 48 hours, You can administer a second dose. • It is recommended to treat animals at the first signs of disease and evaluate their response to treatment at 48 hours. Special precautions • The use of fluoroquinolones should be based on susceptibility testing and taking into account the official and local regulations for the use of antimicrobials. • Overdosing at multiple doses than the recommended one induces erosion of articular cartilage. Caution should be exercised in adjusting the dose and the product should be used with caution in animals with joint disease or growth plate disorders. • Wash hands after use. In case of contact with skin, wash with soap and water immediately. Do not eat, drink or smoke during administration. • People with known hypersensitivity to quinolones should avoid any contact with the product. Wait time Meat: 8 days. Milk: 4 days. conservation mode Store in the original container in order to protect from light. Do not freeze. Comments With veterinary prescription. Presentation Containers of 50 and 100 ml. Reg No. 1.421-ENG   See technical sheet